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Drug delivery systems for treatment of temporomandibular joint osteoarthritis

Affiliation
State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases ,West China Hospital of Stomatology ,Sichuan University ,Chengdu ,China
Huang, Xinqi;
Affiliation
State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases ,West China Hospital of Stomatology ,Sichuan University ,Chengdu ,China
Pan, Xuefeng;
Affiliation
Hospital of Stomatology ,Zunyi Medical University ,Zunyi ,China
Xiong, Xiner;
Affiliation
State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases ,West China Hospital of Stomatology ,Sichuan University ,Chengdu ,China
Zhao, Zhihe;
Affiliation
State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases ,West China Hospital of Stomatology ,Sichuan University ,Chengdu ,China
Cen, Xiao

The number of people suffering from temporomandibular joint osteoarthritis (TMJOA) has been increasing. TMJOA cause joint noise, pain on TMJ and/or masticatory muscles, and restricted mandibular movement, which disturb eating, laughing and conversation, and impose serious lifestyle impediments. Chondrocyte apoptosis, extracellular matrix degradation, synovitis, and subchondral bone remodeling are the main pathological features of TMJOA. Various drug delivery systems are developed to controlled release at specific activation sites with high bioactivity and inhibit rapid dilution to enable long-term therapeutic response, which present great potential for the treatment of TMJOA. This review focuses on recently developed drug delivery systems by different administration in the TMJOA treatment, and summarizes their effects, duration, safety, and limitations, which would pave the way for development of TMJOA therapy.

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License Holder: Copyright © 2022 Huang, Pan, Xiong, Zhao and Cen.

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