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Schisantherin A inhibits cell proliferation by regulating glucose metabolism pathway in hepatocellular carcinoma

Affiliation
National Innovation and Attracting Talents “111” Base ,Key Laboratory of Biorheological Science and Technology ,College of Bioengineering ,Ministry of Education ,Chongqing University ,Chongqing ,China
Feng, Fan;
Affiliation
Chongqing Engineering Research Center of Antitumor Natural Drugs ,Chongqing Three Gorges Medical College ,Chongqing ,China
Pan, Lianhong;
Affiliation
National Innovation and Attracting Talents “111” Base ,Key Laboratory of Biorheological Science and Technology ,College of Bioengineering ,Ministry of Education ,Chongqing University ,Chongqing ,China
Wu, Jiaqin;
Affiliation
School of Comprehensive Health Management ,XiHua University ,Chengdu ,Sichuan ,China
Liu, Mingying;
Affiliation
School of Artificial Intelligence ,Chongqing University of Education ,Chongqing ,China
He, Long;
Affiliation
National Innovation and Attracting Talents “111” Base ,Key Laboratory of Biorheological Science and Technology ,College of Bioengineering ,Ministry of Education ,Chongqing University ,Chongqing ,China
Yang, Li;
Affiliation
Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment ,Chongqing University Cancer Hospital ,Chongqing ,China
Zhou, Wei

Schisantherin A (STA) is a traditional Chinese medicine extracted from the plant Schisandra chinensis , which has a wide range of anti-inflammatory, antioxidant, and other pharmacological effects. This study investigates the anti-hepatocellular carcinoma effects of STA and the underlying mechanisms. STA significantly inhibits the proliferation and migration of Hep3B and HCCLM3 cells in vitro in a concentration-dependent manner. RNA-sequencing showed that 77 genes are upregulated and 136 genes are downregulated in STA-treated cells compared with untreated cells. KEGG pathway analysis showed significant enrichment in galactose metabolism as well as in fructose and mannose metabolism. Further gas chromatography-mass spectrometric analysis (GC-MS) confirmed this, indicating that STA significantly inhibits the glucose metabolism pathway of Hep3B cells. Tumor xenograft in nude mice showed that STA has a significant inhibitory effect on tumor growth in vivo . In conclusion, our results indicate that STA can inhibit cell proliferation by regulating glucose metabolism, with subsequent anti-tumor effects, and has the potential to be a candidate drug for the treatment of liver cancer.

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License Holder: Copyright © 2022 Feng, Pan, Wu, Liu, He, Yang and Zhou.

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