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Recent Advances in Copper-Based Organic Complexes and Nanoparticles for Tumor Theranostics

ORCID
0000-0003-2230-6767
Affiliation
International Institute of Solution Chemistry of Advanced Materials and Technologies, ITMO University, 197101 Saint Petersburg, Russia
Tsymbal, Sergey;
Affiliation
Cancer Center & Department of Breast and Thyroid Surgery, Xiang’an Hospital of Xiamen University, School of Medicine, Xiamen University, 2000 Xiang’an Road East, Xiamen 361101, China
Li, Ge;
Affiliation
International Institute of Solution Chemistry of Advanced Materials and Technologies, ITMO University, 197101 Saint Petersburg, Russia
Agadzhanian, Nikol;
Affiliation
Guangxi University of Chinese Medicine, Nanning 530200, China
Sun, Yuhao;
Affiliation
Day-Care Department, Xinjiang Medical University, Urumqi 830011, China
Zhang, Jiazhennan;
Affiliation
International Institute of Solution Chemistry of Advanced Materials and Technologies, ITMO University, 197101 Saint Petersburg, Russia
Dukhinova, Marina;
ORCID
0000-0002-0239-7473
Affiliation
Laboratory of Biomedical Nanotechnologies, Institute of Cytology of the Russian Academy of Sciences, 194064 Saint Petersburg, Russia
Fedorov, Viacheslav;
ORCID
0000-0002-8539-2239
Affiliation
Laboratory of Biomedical Nanotechnologies, Institute of Cytology of the Russian Academy of Sciences, 194064 Saint Petersburg, Russia
Shevtsov, Maxim

Treatment of drug-resistant forms of cancer requires consideration of their hallmark features, such as abnormal cell death mechanisms or mutations in drug-responding molecular pathways. Malignant cells differ from their normal counterparts in numerous aspects, including copper metabolism. Intracellular copper levels are elevated in various cancer types, and this phenomenon could be employed for the development of novel oncotherapeutic approaches. Copper maintains the cell oxidation levels, regulates the protein activity and metabolism, and is involved in inflammation. Various copper-based compounds, such as nanoparticles or metal-based organic complexes, show specific activity against cancer cells according to preclinical studies. Herein, we summarize the major principles of copper metabolism in cancer cells and its potential in cancer theranostics.

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