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Selenium-enriched yeast modulates the metal bioaccumulation, oxidant status, and inflammation in copper-stressed broiler chickens

Affiliation
Department of Forensic Medicine and Toxicology ,Faculty of Veterinary Medicine ,Mansoura University ,Mansoura ,Egypt
Habotta, Ola A.;
Affiliation
Department of Pathology ,Clinical Medical College and the First Affiliated Hospital of Chengdu Medical College ,Chengdu ,China
Wang, Xiaoyan;
Affiliation
Department of Pathology and Clinical Pathology, Faculty of Veterinary Medicine, Omar Al-Mukhtar University ,Al-Bayda ,Libya
Othman, Hamzah;
Affiliation
Department of Pharmacology, Toxicology and Forensic Medicine, Faculty of Veterinary Medicine, Omar Al-Mukhtar University ,Al-Bayda ,Libya
Aljali, Abdulrahman A.;
Affiliation
Department of Anatomy and Embryology ,Faculty of Veterinary Medicine ,Kafrelsheikh University ,Kafrelsheikh ,Egypt
Gewaily, Mahmoud;
Affiliation
Department of Animal Production ,Faculty of Agriculture ,Kafrelsheikh University ,Kafrelsheikh ,Egypt
Dawood, Mahmoud;
Affiliation
Department of Pathology ,Faculty of Veterinary Medicine ,Alexandria University ,Edfina ,Egypt
Khafaga, Asmaa;
Affiliation
Animal Health Research Institute (AHRI-DOKI) ,Agriculture Research Center ,Kafrelsheikh ,Egypt
Zaineldin, Amr I.;
Affiliation
Institutes for Systems Genetics ,Frontiers Science Center for Disease-Related Molecular Network ,West China Hospital ,Sichuan University ,Chengdu ,China
Singla, Rajeev K.;
Affiliation
Institutes for Systems Genetics ,Frontiers Science Center for Disease-Related Molecular Network ,West China Hospital ,Sichuan University ,Chengdu ,China
Shen, Bairong;
Affiliation
Department of Home Economics ,College of Home Economics ,King Khalid University ,Abha ,Saudi Arabia
Ghamry, Heba I.;
Affiliation
Department of Veterinary Pharmacology ,Faculty of Veterinary Medicine ,University of Sadat City ,Sadat City ,Egypt
Elhussieny, Eman;
Affiliation
Department of Veterinary Pharmacology ,Faculty of Veterinary Medicine ,Menoufia University ,Shebin Elkoum ,Egypt
El-Mleeh, Amany;
Affiliation
Clinical Sciences Department, College of Medicine, Princess Nourah bint Abdulrahman University ,Riyadh ,Saudi Arabia
Ibrahim, Samah F.;
Affiliation
Department of Forensic Medicine and Toxicology ,Faculty of Veterinary Medicine ,Benha University ,Toukh ,Egypt
Abdeen, Ahmed

Copper (Cu) could be seriously hazardous when present at excessive levels, despite its vital contribution to various cellular processes. Selenium-enriched yeast (SeY) was reported to improve the health and metabolic status in broiler chicken. Hence, our study was endeavored to illustrate the mitigating efficacy of SeY on Cu-induced hepatic and renal damage. Cobb chicks aged 1 day were allocated into four experimental groups and offered a basal diet, SeY (0.5 mg/kg), CuSO 4 (300 mg/kg), or SeY plus CuSO 4 in their diets for 42 days. Our results revealed that SeY supplement antagonized significantly the Cu accumulation in livers and kidneys of exposed birds. Marked declines were also detected in the AST, ALT, urea, and creatinine levels, besides marked increases in total protein, glycerides, and cholesterol in the SeY-supplemented group. Moreover, enhancement of cellular antioxidant biomarkers (superoxide dismutase, CAT, GPx, and GSH) along with lowered MDA contents were achieved by SeY in hepatic and renal tissues. Further, SeY exerted a noteworthy anti-inflammatory action as indicated by decreased inflammatory biomarkers (IL-1β and TNF-α) and NO levels in both organs. Noticeable histopathological alterations of both organs further validated the changes in the markers mentioned above. To sum up, our findings indicate that SeY can be considered a potential feed supplement for alleviating Cu-induced hepatic and renal damage in broilers, possibly via activation of antioxidant molecules and lessening the inflammatory stress.

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License Holder: Copyright © 2022 Habotta, Wang, Othman, Aljali, Gewaily, Dawood, Khafaga, Zaineldin, Singla, Shen, Ghamry, Elhussieny, El-Mleeh, Ibrahim and Abdeen.

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