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Diagnostic and therapeutic strategies for non-alcoholic fatty liver disease

Affiliation
Key Laboratory of Receptors-Mediated Gene Regulation ,Hebi Key Laboratory of Liver Disease ,School of Basic Medical Sciences ,The People’s Hospital of Hebi ,Henan University ,Kaifeng ,China
Fu, Yajie;
Affiliation
Key Laboratory of Receptors-Mediated Gene Regulation ,Hebi Key Laboratory of Liver Disease ,School of Basic Medical Sciences ,The People’s Hospital of Hebi ,Henan University ,Kaifeng ,China
Zhou, Yanzhi;
Affiliation
Key Laboratory of Receptors-Mediated Gene Regulation ,Hebi Key Laboratory of Liver Disease ,School of Basic Medical Sciences ,The People’s Hospital of Hebi ,Henan University ,Kaifeng ,China
Shen, Linhu;
Affiliation
Key Laboratory of Receptors-Mediated Gene Regulation ,Hebi Key Laboratory of Liver Disease ,School of Basic Medical Sciences ,The People’s Hospital of Hebi ,Henan University ,Kaifeng ,China
Li, Xuewen;
Affiliation
Key Laboratory of Receptors-Mediated Gene Regulation ,Hebi Key Laboratory of Liver Disease ,School of Basic Medical Sciences ,The People’s Hospital of Hebi ,Henan University ,Kaifeng ,China
Zhang, Haorui;
Affiliation
Key Laboratory of Receptors-Mediated Gene Regulation ,Hebi Key Laboratory of Liver Disease ,School of Basic Medical Sciences ,The People’s Hospital of Hebi ,Henan University ,Kaifeng ,China
Cui, Yeqi;
Affiliation
Key Laboratory of Receptors-Mediated Gene Regulation ,Hebi Key Laboratory of Liver Disease ,School of Basic Medical Sciences ,The People’s Hospital of Hebi ,Henan University ,Kaifeng ,China
Zhang, Ke;
Affiliation
Key Laboratory of Receptors-Mediated Gene Regulation ,Hebi Key Laboratory of Liver Disease ,School of Basic Medical Sciences ,The People’s Hospital of Hebi ,Henan University ,Kaifeng ,China
Li, Weiguo;
Affiliation
Key Laboratory of Receptors-Mediated Gene Regulation ,Hebi Key Laboratory of Liver Disease ,School of Basic Medical Sciences ,The People’s Hospital of Hebi ,Henan University ,Kaifeng ,China
Chen, Wei-dong;
Affiliation
Key Laboratory of Receptors-Mediated Gene Regulation ,Hebi Key Laboratory of Liver Disease ,School of Basic Medical Sciences ,The People’s Hospital of Hebi ,Henan University ,Kaifeng ,China
Zhao, Shizhen;
Affiliation
Key Laboratory of Receptors-Mediated Gene Regulation ,Hebi Key Laboratory of Liver Disease ,School of Basic Medical Sciences ,The People’s Hospital of Hebi ,Henan University ,Kaifeng ,China
Li, Yunfu;
Affiliation
Key Laboratory of Receptors-Mediated Gene Regulation ,Hebi Key Laboratory of Liver Disease ,School of Basic Medical Sciences ,The People’s Hospital of Hebi ,Henan University ,Kaifeng ,China
Ye, Wenling

The global incidence rate of non-alcoholic fatty liver disease (NAFLD) is approximately 25%. With the global increase in obesity and its associated metabolic syndromes, NAFLD has become an important cause of chronic liver disease in many countries. Despite recent advances in pathogenesis, diagnosis, and therapeutics, there are still challenges in its treatment. In this review, we briefly describe diagnostic methods, therapeutic targets, and drugs related to NAFLD. In particular, we focus on evaluating carbohydrate and lipid metabolism, lipotoxicity, cell death, inflammation, and fibrosis as potential therapeutic targets for NAFLD. We also summarized the clinical research progress in terms of drug development and combination therapy, thereby providing references for NAFLD drug development.

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License Holder: Copyright © 2022 Fu, Zhou, Shen, Li, Zhang, Cui, Zhang, Li, Chen, Zhao, Li and Ye.

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