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Baicalin regulates stem cells as a creative point in the treatment of climacteric syndrome

Affiliation
State Key Laboratory of Component-Based Chinese Medicine ,Institute of Traditional Chinese Medicine ,Tianjin University of Traditional Chinese Medicine ,Tianjin ,China
Wei, Qian;
Affiliation
State Key Laboratory of Component-Based Chinese Medicine ,Institute of Traditional Chinese Medicine ,Tianjin University of Traditional Chinese Medicine ,Tianjin ,China
Hao, Xia;
Affiliation
Department of Rehabilitation Sciences ,The Hong Kong Polytechnic University ,Hong Kong ,Hong Kong SAR, China
Lau, Benson Wui-Man;
Affiliation
School of Integrative Medicine ,Tianjin University of Traditional Chinese Medicine ,Tianjin ,China
Wang, Shaoxia;
Affiliation
State Key Laboratory of Component-Based Chinese Medicine ,Institute of Traditional Chinese Medicine ,Tianjin University of Traditional Chinese Medicine ,Tianjin ,China
Li, Yue

It is widely acknowledged that the climacteric syndrome negatively affects women’s quality of life and leads to cerebral ischemic injury, osteoporosis and cardiovascular disease. One of the main active ingredients in Radix Scutellariae, Baicalin, has been established to possess a wide range of pharmacological effects and is beneficial in enhancing osteogenic differentiation and cardiovascular disease. Baicalin’s profound metabolic impact on various stem cell populations and their fate specification could improve the efficiency of stem cell therapy for climacteric syndrome. However, Baicalin-mediated processes are complex and many of the underlying mechanisms are not fully fathomed yet. This review aims to shed light on the regulatory role of Baicalin on the diverse behaviors of distinct stem cell populations and provide a good cell source for stem cell therapy to broaden the therapeutic landscape for climacteric syndrome patients.

Graphical Abstract This review summarizes the regulatory role of Baicalin on the diverse behaviors of distinct stem cell populations and emphasizes the potential applications of Baicalin and stem cell therapy in climacteric syndrome.

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License Holder: Copyright © 2022 Wei, Hao, Lau, Wang and Li.

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