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Berbamine inhibits RANKL- and M-CSF-mediated osteoclastogenesis and alleviates ovariectomy-induced bone loss

Affiliation
Department of Orthopaedics ,Shanghai Sixth People’s Hospital ,Shanghai ,China
Qi, Guobin;
Affiliation
Department of Orthopaedics ,Shanghai Sixth People’s Hospital ,Shanghai ,China
Jiang, Zengxin;
Affiliation
Department of Orthopedic Surgery ,Shanghai TCM-Integrated Hospital Shanghai University of TCM ,Shanghai ,China
Lu, Wei;
Affiliation
Department of Orthopedic Surgery ,Jinshan Hospital ,Fudan University ,Shanghai ,China
Li, Defang;
Affiliation
Department of Orthopedic Surgery ,Jinshan Hospital ,Fudan University ,Shanghai ,China
Chen, Weibing;
Affiliation
Department of Radiology ,Jinshan Hospital ,Fudan University ,Shanghai ,China
Yang, Xiuying;
Affiliation
Department of Orthopedic Surgery ,Jinshan Hospital ,Fudan University ,Shanghai ,China
Ding, Lei;
Affiliation
Department of Orthopaedics ,Shanghai Sixth People’s Hospital ,Shanghai ,China
Yuan, Hengfeng

Osteoporosis is a common public health problem characterized by decreased bone mass, increased bone brittleness and damage to the bone microstructure. Excessive bone resorption by osteoclasts is the main target of the currently used drugs or treatment for osteoporosis. Effective antiresorptive drugs without side effects following long-term administration have become a major focus of anti-osteoporotic drugs. In the present study, we investigated the effect of berbamine, a small molecule natural product from Berberis amurensis Rupr , a traditional Chinese medicine, on RANKL-induced osteoclast differentiation in vitro and ovariectomy-induced bone loss in vivo . The results demonstrated that berbamine at a safe and effective dose inhibited osteoclastogenesis and bone resorption function in vitro by suppressing the nuclear factor-κB signaling pathway. In addition, berbamine protected against osteoporosis by inhibiting osteoclastogenesis and bone resorption function without affecting osteogenesis in the ovariectomy mouse model. These findings revealed that berbamine has a protective role against osteoporosis and may represent a novel promising treatment strategy for osteoporosis.

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License Holder: Copyright © 2022 Qi, Jiang, Lu, Li, Chen, Yang, Ding and Yuan.

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