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Natural drugs targeting inflammation pathways can be used to treat atherosclerosis

Affiliation
Innovative Institute of Chinese Medicine and Pharmacy ,Shandong University of Traditional Chinese Medicine Jinan ,Jinan ,China
Song, Xiayinan;
Affiliation
Experimental Center ,Shandong University of Traditional Chinese Medicine ,Jinan ,China
Wang, Xiaoming;
Affiliation
Innovative Institute of Chinese Medicine and Pharmacy ,Shandong University of Traditional Chinese Medicine Jinan ,Jinan ,China
Wang, Danyang;
Affiliation
Affiliated Zhongshan Hospital of Dalian University ,Dalian ,China
Zheng, Zhenzhen;
Affiliation
Innovative Institute of Chinese Medicine and Pharmacy ,Shandong University of Traditional Chinese Medicine Jinan ,Jinan ,China
Li, Jie;
Affiliation
Innovative Institute of Chinese Medicine and Pharmacy ,Shandong University of Traditional Chinese Medicine Jinan ,Jinan ,China
Li, Yunlun

Atherosclerosis (AS) is the chronic gradual degradation of arteries in combination with inflammation. Currently, the main research focus has been on interactions between inflammatory cells, inflammatory mediators, and immune mechanisms, while some studies have reported natural drugs were exerting a critical role against AS, whereas the usage of natural drugs was always limited by various factors such as poor penetration across biological barriers, low bioavailability, and unclear mechanisms. Herein, we reviewed the potential targets for inflammation against AS, discussed the underlying mechanisms of natural drugs for AS, particularly highlighted the dilemma of current research, and finally, offered perspectives in this field.

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License Holder: Copyright © 2022 Song, Wang, Wang, Zheng, Li and Li.

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