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The intervention effect of Amygdalus mongolica oil on the metabolomics and intestinal flora in pulmonary fibrosis

Affiliation
Department of Pharmacy ,Baotou Medical College ,Baotou ,China
Li, Qian;
Affiliation
Department of Pharmacy ,Baotou Medical College ,Baotou ,China
Zhou, Hong-Bing;
Affiliation
Department of Pharmacy ,Baotou Medical College ,Baotou ,China
Liu, Jia-Qi;
Affiliation
Department of Pharmacy ,Baotou Medical College ,Baotou ,China
Bai, Wan-Fu;
Affiliation
Department of Pharmacy ,Baotou Medical College ,Baotou ,China
Wang, Jia;
Affiliation
Institute of Bioactive Substance and Function of Mongolian Medicine and Chinese Materia Medica, Baotou Medical College ,Baotou ,China
Yang, Zhan-Jun;
Affiliation
Department of Pharmacy ,Baotou Medical College ,Baotou ,China
Qiu, Min;
Affiliation
Department of Pharmacy ,Baotou Medical College ,Baotou ,China
Chang, Hong;
Affiliation
Department of Pharmacy ,Baotou Medical College ,Baotou ,China
Shi, Song-Li

Amygdalus mongolica oil is rich in unsaturated fatty acids such as inoleic acid (47.11%) and oleic acid (23.81%). Our research demonstrates that it exerts a protective effect on rat models of pulmonary fibrosis, however, little is known regarding the underlying mechanism of action. This study aimed to characterize the therapeutic mechanism of action of A. mongolica oil on bleomycin-induced pulmonary fibrosis in rats. A. mongolica oil appears to regulate the levels of potential key serum biomarkers which include tetrahydrobiopterin, L-serine, citrulline and estradiol to participate in folate biosynthesis, glycine, serine and threonine metabolism, arginine biosynthesis and steroid hormone biosynthesis. And it also enriched intestinal microbial abundance, homogeneity and modulated the abundance of Duncaniell, Desulfovibrio , Peptococcaceae _unclassified , Dubosiella , Tyzzerella , Lachnospiraceae _NK4A136_group, Lactobacillus, Clostridiales_unclassified to exert a protective effect against pulmonary fibrosis. A. mongolica oil appears to confer protective effects against pulmonary fibrosis by affecting the level of pulmonary fibrosis metabolites and the abundance of related intestinal flora through multiple targets, as evidenced by our untargeted LC-MS/MS metabonomics evaluation and 16S rDNA sequencing technology.

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License Holder: Copyright © 2022 Li, Zhou, Liu, Bai, Wang, Yang, Qiu, Chang and Shi.

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