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Role of microRNAs in the regulation of blood-brain barrier function in ischemic stroke and under hypoxic conditions in vitro

Affiliation
Department of Anaesthesiology ,Intensive Care ,Emergency and Pain Medicine ,University Hospital Würzburg ,Würzburg ,Germany
Sun, Aili;
Affiliation
Institute of Experimental Neurosurgery ,Charité—Universitätsmedizin Berlin ,Berlin ,Germany
Blecharz-Lang, Kinga G.;
Affiliation
Laboratory of Molecular Biology ,Institute of Physiotherapy and Health Sciences ,Academy of Physical Education ,Katowice ,Poland
Małecki, Andrzej;
Affiliation
Department of Anaesthesiology ,Intensive Care ,Emergency and Pain Medicine ,University Hospital Würzburg ,Würzburg ,Germany
Meybohm, Patrick;
Affiliation
Laboratory of Molecular Biology ,Institute of Physiotherapy and Health Sciences ,Academy of Physical Education ,Katowice ,Poland
Nowacka-Chmielewska, Marta M.;
Affiliation
Department of Anaesthesiology ,Intensive Care ,Emergency and Pain Medicine ,University Hospital Würzburg ,Würzburg ,Germany
Burek, Malgorzata

The blood-brain barrier (BBB) is a highly specialized structure that separates the brain from the blood and allows the exchange of molecules between these two compartments through selective channels. The breakdown of the BBB is implicated in the development of severe neurological diseases, especially stroke and traumatic brain injury. Oxygen-glucose deprivation is used to mimic stroke and traumatic brain injury in vitro . Pathways that trigger BBB dysfunction include an imbalance of oxidative stress, excitotoxicity, iron metabolism, cytokine release, cell injury, and cell death. MicroRNAs are small non-coding RNA molecules that regulate gene expression and are emerging as biomarkers for the diagnosis of central nervous system (CNS) injuries. In this review, the regulatory role of potential microRNA biomarkers and related therapeutic targets on the BBB is discussed. A thorough understanding of the potential role of various cellular and linker proteins, among others, in the BBB will open further therapeutic options for the treatment of neurological diseases.

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License Holder: Copyright © 2022 Sun, Blecharz-Lang, Małecki, Meybohm, Nowacka-Chmielewska and Burek.

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