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Selecting the right therapeutic target for kidney disease

Affiliation
Bioscience Renal ,Research and Early Development ,Cardiovascular ,Renal and Metabolism ,BioPharmaceuticals R&D ,AstraZeneca ,Gothenburg ,Sweden
Buvall, Lisa;
Affiliation
Bioscience Renal ,Research and Early Development ,Cardiovascular ,Renal and Metabolism ,BioPharmaceuticals R&D ,AstraZeneca ,Gothenburg ,Sweden
Menzies, Robert I.;
Affiliation
Bioscience Renal ,Research and Early Development ,Cardiovascular ,Renal and Metabolism ,BioPharmaceuticals R&D ,AstraZeneca ,Gothenburg ,Sweden
Williams, Julie;
Affiliation
Bioscience Renal ,Research and Early Development ,Cardiovascular ,Renal and Metabolism ,BioPharmaceuticals R&D ,AstraZeneca ,Cambridge ,United Kingdom
Woollard, Kevin J.;
Affiliation
Translational Science and Experimental Medicine ,Research and Early Development ,Cardiovascular ,Renal and Metabolism ,BioPharmaceuticals R&D ,AstraZeneca ,Gothenburg ,Sweden
Kumar, Chanchal;
Affiliation
Bioscience Renal ,Research and Early Development ,Cardiovascular ,Renal and Metabolism ,BioPharmaceuticals R&D ,AstraZeneca ,Gothenburg ,Sweden
Granqvist, Anna B.;
Affiliation
Bioscience Renal ,Research and Early Development ,Cardiovascular ,Renal and Metabolism ,BioPharmaceuticals R&D ,AstraZeneca ,Gothenburg ,Sweden
Fritsch, Maria;
Affiliation
Bioscience Renal ,Research and Early Development ,Cardiovascular ,Renal and Metabolism ,BioPharmaceuticals R&D ,AstraZeneca ,Cambridge ,United Kingdom
Feliers, Denis;
Affiliation
Translational Science and Experimental Medicine ,Research and Early Development ,Cardiovascular ,Renal and Metabolism ,BioPharmaceuticals R&D ,AstraZeneca ,Gothenburg ,Sweden
Reznichenko, Anna;
Affiliation
Functional Genomics ,Discovery Sciences ,R&D ,AstraZeneca ,Cambridge ,United Kingdom
Gianni, Davide;
Affiliation
Centre for Genomics Research ,Discovery Sciences ,R&D ,AstraZeneca ,Cambridge ,United Kingdom
Petrovski, Slavé;
Affiliation
Data Sciences & Quantitative Biology ,Discovery Sciences ,R&D ,AstraZeneca ,Cambridge ,United Kingdom
Bendtsen, Claus;
Affiliation
Translational Genomics ,Discovery Sciences ,R&D ,AstraZeneca ,Gothenburg ,Sweden
Bohlooly-Y, Mohammad;
Affiliation
Centre for Genomics Research ,Discovery Sciences ,R&D ,AstraZeneca ,Cambridge ,United Kingdom
Haefliger, Carolina;
Affiliation
Bioscience Renal ,Research and Early Development ,Cardiovascular ,Renal and Metabolism ,BioPharmaceuticals R&D ,AstraZeneca ,Gothenburg ,Sweden
Danielson, Regina Fritsche;
Affiliation
Bioscience Renal ,Research and Early Development ,Cardiovascular ,Renal and Metabolism ,BioPharmaceuticals R&D ,AstraZeneca ,Gothenburg ,Sweden
Hansen, Pernille B. L.

Kidney disease is a complex disease with several different etiologies and underlying associated pathophysiology. This is reflected by the lack of effective treatment therapies in chronic kidney disease (CKD) that stop disease progression. However, novel strategies, recent scientific breakthroughs, and technological advances have revealed new possibilities for finding novel disease drivers in CKD. This review describes some of the latest advances in the field and brings them together in a more holistic framework as applied to identification and validation of disease drivers in CKD. It uses high-resolution ‘patient-centric’ omics data sets, advanced in silico tools (systems biology, connectivity mapping, and machine learning) and ‘state-of-the-art‘ experimental systems (complex 3D systems in vitro , CRISPR gene editing, and various model biological systems in vivo ). Application of such a framework is expected to increase the likelihood of successful identification of novel drug candidates based on strong human target validation and a better scientific understanding of underlying mechanisms.

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License Holder: Copyright © 2022 Buvall, Menzies, Williams, Woollard, Kumar, Granqvist, Fritsch, Feliers, Reznichenko, Gianni, Petrovski, Bendtsen, Bohlooly-Y, Haefliger, Danielson and Hansen.

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